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The FDA announced the approval of your new weight-loss drug on Sept. 11, 2014. The drug name is Contrave.

Using two separate drugs to shed pounds can be very effective you will find combinations as you're watching FDA now awaiting approval. When dealing with weight loss and the those who go through it you should err on the side of caution and allow FDA do its job and demand some investigation be done in order that the public recognizes the side effects and hazards of the medications before we drive them. Keep in mind that drug companies are in business to earn money and that they would say everything to keep people on his or her medications.

Researchers found that participants investing in this drug for any year, lost excess weight within four weeks and have kept the extra weight off through the 56 weeks with the study. Contrave is a combination from the drugs naltrexone and bupropion, which generally seems to reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, which can make them more potent and safer.

Combo-pilling will be the newest fad or even better the newest to come under scrutiny and so it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular could be the fact that as of right now there are not any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is that doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be approved by the FDA.

Seizures certainly are a side effect with Contrave and mustn't be taken in people who have seizure disorders. The drug can also raise blood pressure and heartbeat, and mustn't be used in people with a history of cardiac event or stroke in the previous six months. Blood pressure and pulse should also be measured before beginning the drug and throughout therapy with all the drug.

The FDA also warned that Contrave can raise blood pressure levels and pulse rate and must stop used in patients with uncontrolled high blood pressure, and also by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the brain) disease. Patients having a history of heart attack or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded in the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes using a boxed warning to alert medical researchers and patients towards the increased likelihood of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.


Suboxone consists of two drugs; buprenorphine and naloxone. The naloxone is irrelevant when the addict uses the medication properly, but if your tablet is dissolved in water and injected the naloxone will result in instant withdrawal. When suboxone is used correctly, the naloxone is destroyed inside liver shortly after uptake from your intestines and it has no therapeutic effect. Buprenorphine will be the active substance; it really is absorbed under the tongue (and during the entire mouth) but destroyed through the liver if swallowed. There is a formulation of buprenorphine without naloxone called subutex; I have used this formulation when the patient has apparent problems from naloxone, including headaches after dosing with suboxone. I have treated addicts who've had gastric bypass, the location where the first area of the intestine is bypassed and also the stomach contents empty into a more distal part of the small intestine. In such cases the naloxone escapes ?first pass metabolism', the method with normal anatomy where the drug is taken up by the duodenum and transferred straight to the liver with the portal vein, where it is quickly and completely destroyed. After gastric bypass naloxone can be taken up by portions of the intestine which are not served with the portal system, causing blood levels of naloxone sufficient to cause brief, relatively mild withdrawal symptoms.